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KMID : 1199120100340040229
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Korean Diabetes Journal
2010 Volume.34 No. 4 p.229 ~ p.236
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Polymorphisms of the Reg1α Gene and Early Onset Type 2 Diabetes in the Korean Population
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Koo Bo-Kyung
Cho Young-Min
Kimm Ku-Chan
Lee Jong-Young
Oh Berm-Seok
Park Byung-Lae
Cheong Hyun-Sub
Shin Hyoung-Doo
Ko Kyung-Soo
Park Sang-Gyu
Lee Hong-Kyu
Park Kyong-Soo
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Abstract
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Background: The Reg gene has been reported to be expressed in regenerating islets and Reg1 protein to be up-regulated at an early stage of diabetes in mice. As human Reg1α is homologous with murine Reg1, we investigated whether common variants in Reg1α are associated with type 2 diabetes in the Korean population.
Methods: We sequenced the Reg1α gene to identify common polymorphisms using 24 Korean DNA samples. Of 11 polymorphisms found, five common ones (g.-385T>C [rs10165462], g.-36T>G [rs25689789], g.209G>T [rs2070707], g.1385C>G [novel], and g.2199G>A [novel]) were genotyped in 752 type 2 diabetic patients and 642 non-diabetic subjects.
Results: No polymorphism was associated with the risk of type 2 diabetes. However, g.-385C and g.2199A lowered the risk of early-onset type 2 diabetes, defined as a diagnosis in subjects whose age at diagnosis was 25 years or more but less than 40 years (odds ratio [OR], 0.721 [0.535 to 0.971] and 0.731 [0.546 to 0.977] for g.-385C and g.2199A, respectively) and g.1385G increased the risk of early-onset diabetes (OR, 1.398 [1.055 to 1.854]). Although adjusting for errors in multiple hypotheses-testing showed no statistically significant association between the three individual polymorphisms and early-onset diabetes, the haplotype H1, composed of g.-385C, g.1385C, and g.2199A, was associated with a reduced risk of early-onset diabetes (OR, 0.590 [0.396 to 0.877], P = 0.009).
Conclusion: Polymorphisms in the Reg1α were not found to be associated with overall susceptibility to type 2 diabetes, though some showed modest associations with early-onset type 2 diabetes in the Korean population.
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KEYWORD
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Diabetes mellitus, type 2, Polymorphism, Reg1α gene
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